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ORIGINAL ARTICLE
Year : 2023  |  Volume : 6  |  Issue : 1  |  Page : 32-37

The relationship between coronavirus disease-2019-positive patients and plasma interleukins and transforming growth factor-β levels


1 Department of Histology and Embryology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey; DESAM Institute, Near East University, Nicosia, North Cyprus
2 DESAM Institute, Near East University, Nicosia, North Cyprus; PCR Unit, Clinical Laboratory, Faculty of Medicine, Kocaeli University, Mugla, Turkey
3 Department of Histology and Embryology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey
4 Department of Clinical Microbiology and Infection Diseases, Faculty of Medicine, Kocaeli University, Mugla, Turkey
5 Derince Training and Research Hospital, Health Science University, Kocaeli, Mugla, Turkey
6 DESAM Institute, Near East University, Nicosia, North Cyprus; Department of Clinical Microbiology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey

Correspondence Address:
Melike Ozgul-Onal
Department of Histology and Embryology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jnsm.jnsm_37_22

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Objective: The aim of this study is to reveal the relationship between the cytokine plasma levels and symptoms of coronavirus disease-2019 (COVID-19)-positive patients, which is characterized by serious respiratory syndromes. Materials and Methods: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-positive patients were evaluated in four groups. Group 1 patients had no symptoms. Group 2 patients were mildly symptomatic. Group 3 patients had multiple symptoms. Group 4 patients had all symptoms of acute respiratory distress syndrome. Analysis of interleukin (IL)-17A, transforming growth factor-β1 (TGF-β1), and IL-6 concentrations in plasma samples taken from patients were examined by enzyme-linked immunosorbent assay method. Results: IL-17A levels were increased in parallel with the clinical condition in all patients. TGF-β1 was only observed in patients in Groups 3 and 4, and IL-6 was only observed in Group 4 patients. Conclusion: It is known that many cytokines are involved in the development of different viral infections and viral invasion always triggers an inflammatory response. The profile of inflammatory markers may be used to classify COVID-19 patients. In conclusion of this study, it is suggested that the level of cytokines which is changed according to the patient's clinical status should be used to evaluate the response of SARS-CoV-2 treatment. IL-17A, TGF-β1, and IL-6 concentrations in plasma levels could be good prognostic indicators of COVID-19.


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